Vega, Marta Ramos, Henrik H. Hansen, Camilla Stampe Jensen, Evdoxia Alexiou, Martin R. Madsen, Franziska Wichern, … and Jacob Hecksher-Sørensen. 2025. “Transferrin Receptor-Binding Blood-Brain Barrier Shuttle Enhances Brain Delivery and Plaque-Clearing Efficacy of a Therapeutic Anti-Aβ Antibody.” Fluids and Barriers of the CNS 22. (link).

Augustin, Robert, Anouk Oldenburger, Tamara Baader-Pagler, Tina Zimmermann, Jens Borghardt , Jacob Hecksher-Sørensen, …., Peter Haebel. 2025. “Novel NPY2R agonist BI 1820237 provides synergistic anti-obesity efficacy when combined with the GCGR/GLP-1R dual agonist survodutide.” Molecular Metabolism 99 (link)

Roostalu, Urmas, Henrik H. Hansen, and Jacob Hecksher-Sørensen. 2024. “3D Light-Sheet Fluorescence Microscopy in Preclinical and Clinical Drug Discovery.” Drug Discovery Today 29 (11) (link)

Dedic, Nina, Lien Wang, Eva Hajos-Korcsok, Jacob Hecksher-Sørensen, Urmas Roostalu, Steven P. Vickers, Serena Wu, et al. 2024. “TAAR1 Agonists Improve Glycemic Control, Reduce Body Weight and Modulate Neurocircuits Governing Energy Balance and Feeding.” Molecular Metabolism 80 (link)

Barbut, Denise, William A Kinney, Hsiao-Huei Chen, Alexandre F R Stewart, Jacob Hecksher-Sørensen, Chen Zhang, Alexander Fleming, Michael Zemel, and Michael Zasloff. 2024. “A Novel, Centrally Acting Mammalian Aminosterol, ENT-03, Induces Weight Loss in Obese and Lean Rodents.” Diabetes, Obesity & Metabolism 26 (12): 5701–12. (link)

Perens, Johanna, Casper Gravesen Salinas, Urmas Roostalu, Jacob Lercke Skytte, Carsten Gundlach, Jacob Hecksher-Sørensen, Anders Bjorholm Dahl, and Tim B Dyrby. 2023. “Multimodal 3D Mouse Brain Atlas Framework with the Skull-Derived Coordinate System.” Neuroinformatics, (link)

Skovbjerg, Grethe, Urmas Roostalu, Casper G. Salinas, Jacob L. Skytte, Johanna Perens, Christoffer Clemmensen, Lisbeth Elster, Camilla K. Frich, Henrik H. Hansen, and Jacob Hecksher-Sørensen. 2023. “Uncovering CNS Access of Lipidated Exendin-4 Analogues by Quantitative Whole-Brain 3D Light Sheet Imaging.” Neuropharmacology 238 (link)

Falk, Sarah, Jonas Petersen, Charlotte Svendsen, Cesar R. Romero-Leguizamón, Søren Heide Jørgensen, Nathalie Krauth, Mette Q. Ludwig, et al. 2023. “GLP-1 and Nicotine Combination Therapy Engages Hypothalamic and Mesolimbic Pathways to Reverse Obesity.” Cell Reports 42 (5). (link)

Perens, Johanna, and Jacob Hecksher-Sørensen. 2022. “Digital Brain Maps and Virtual Neuroscience: An Emerging Role for Light-Sheet Fluorescence Microscopy in Drug Development.” Frontiers in Neuroscience 16 (link)

Boland, Brandon B., Rhianna C. Laker, Siobhan O’Brien, Sadichha Sitaula, Isabelle Sermadiras, Jens Christian Nielsen, Pernille Barkholt, et al. 2022. “Peptide-YY3-36/Glucagon-like Peptide-1 Combination Treatment of Obese Diabetic Mice Improves Insulin Sensitivity Associated with Recovered Pancreatic β-Cell Function and Synergistic Activation of Discrete Hypothalamic and Brainstem Neuronal Circuitries.” Molecular Metabolism 55 (link)

Skovbjerg, Grethe, Urmas Roostalu, Henrik H. Hansen, Thomas A. Lutz, Christelle le Foll, Casper G. Salinas, Jacob L. Skytte, Jacob Jelsing, Niels Vrang, and Jacob Hecksher-Sørensen. 2021. “Whole-Brain Mapping of Amylin-Induced Neuronal Activity in Receptor Activity–Modifying Protein 1/3 Knockout Mice.” European Journal of Neuroscience 54 (1): 4154–66. (link)

Perens, Johanna, Jacob Lercke Skytte, Casper Gravesen Salinas, Jacob Hecksher-Sorensen, Tim B. Dyrby, and Anders Bjorholm Dahl. 2021. “Comparative Study of Voxel-Based Statistical Analysis Methods for Fluorescently Labelled and Light Sheet Imaged Whole-Brain Samples.” Proceedings - International Symposium on Biomedical Imaging 2021-April:1433–37. (link)

Perens, Johanna, Casper Gravesen Salinas, Jacob Lercke Skytte, Urmas Roostalu, … and Jacob Hecksher-Sørensen. 2021. “An Optimized Mouse Brain Atlas for Automated Mapping and Quantification of Neuronal Activity Using IDISCO+ and Light Sheet Fluorescence Microscopy.” Neuroinformatics 19. (link)