Vibraint foundational papers 

Perens, J., C. G. Salinas, J. L. Skytte, U. Roostalu, A. B. Dahl, T. B. Dyrby, F. Wichern, P. Barkholt, N. Vrang, J. Jelsing, and J. Hecksher-Sørensen. 2021. “An Optimized Mouse Brain Atlas for Automated Mapping and Quantification of Neuronal Activity Using iDISCO+ and Light Sheet Fluorescence Microscopy.” Neuroinformatics 19(3) (link). 

Perens, J., C. G. Salinas, U. Roostalu, J. L. Skytte, C. Gundlach, J. Hecksher-Sørensen, A. B. Dahl, and T. B. Dyrby. 2023. “Multimodal 3D Mouse Brain Atlas Framework with the Skull-Derived Coordinate System.” Neuroinformatics (link). 

Perens, J., and J. Hecksher-Sørensen. 2022. “Digital Brain Maps and Virtual Neuroscience: An Emerging Role for Light-Sheet Fluorescence Microscopy in Drug Development.” Frontiers in Neuroscience 16 (link). 

Secher, A., J. Jelsing, A. F. Baquero, J. Hecksher-Sørensen, ..., L. B. Knudsen. 2014. “The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.” Journal of Clinical Investigation 124(10) (link). 

Featured on the front cover

Kanatani, S., J. C. Kreutzmann, Y. Li, Z. West, L. L. Larsen, D. V. Nikou, I. Eidhof, A. Walton, S. Zhang, L. R. Rodríguez-Kirby, J. L. Skytte, C. G. Salinas, ..., J. Hecksher-Sørensen, ..., P. Uhlén. 2024. “Whole-brain spatial transcriptional analysis at cellular resolution.” Science 386(6724) (link). 

Buller, S., E. O. Staricoff, C. Riches, A. Tsang, G. Giavara, M. Josipovic, K. Ikemura, G. Opoku, I. Sato, S. Hirohata, S. Stenzel, S. G. Nayar, M. Ramos Vega, J. Hecksher-Sørensen, ..., C. Blouet. 2026. “Adaptive oligodendrogenesis regulates blood-hypothalamus barrier permeability, hypothalamic glucose sensing and systemic glucose homeostasis in male mice.” Molecular Metabolism 112 (link).

Komi, S., A. Winther, G. A. Houser, T. Topilko, R. J. F. Sørensen, S. D. Larsen, M. C. A. Bonfils, G. Li, and R. W. Berg. 2026. “Spatial and network principles behind neural generation of locomotion.” Nature Communications 17(1) (link).

Wang, J. G., C. S. Xu, C. L. Murrell, M. R. Barrett, G. C. Basu, L. Z. Fang, Y. Chen, F. Schoukroun, T. Topilko, J. Perens, J. Hecksher-Sørensen, ..., A. V. Kravitz. 2026. “Ventral pallidal GABAergic neurons control hedonic feeding and obesity.” bioRxiv, preprint (link).

Li, Y., A. Walton, J. C. Kreutzmann, L. Lydolph Larsen, I. Eidhof, J. L. Skytte, C. G. Salinas, U. Roostalu, J. Hecksher-Sørensen, S. Kanatani, and P. Uhlén. 2026. “Whole-organ spatial transcriptional analysis at cellular resolution using TRISCO.” Nature Protocols (link).

Zimmermann, T., K. Bleymehl, P. Haebel, J. Perens, U. Roostalu, J. Hecksher-Sørensen, ..., R. Augustin. 2026. “Survodutide acts through circumventricular organs in the brain and activates neuronal regions associated with appetite regulation.” Molecular Metabolism 105 (link).

Vega, M. R., H. H. Hansen, C. S. Jensen, E. Alexiou, M. R. Madsen, F. Wichern, M. S. Kristiansen, J. L. Skytte, C. G. Salinas, F. Sotty, A. Jensen, S. Vergo, and J. Hecksher-Sørensen. 2025. “Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and plaque-clearing efficacy of a therapeutic anti-Aβ antibody.” Fluids and Barriers of the CNS 22(1) (link).

Augustin, R., A. Oldenburger, T. Baader-Pagler, T. Zimmermann, J. Borghardt, J. Hecksher-Sørensen, ..., P. Haebel. 2025. “Novel NPY2R agonist BI 1820237 provides synergistic anti-obesity efficacy when combined with the GCGR/GLP-1R dual agonist survodutide.” Molecular Metabolism 99 (link).

Houser, G., A. Vieites Prado, T. Topilko, C. Nguyen, P. Gaspar, and N. Renier. 2025. “Organization and development of bilateral somatosensory feedback projections in mice.” iScience 28(6) (link).

Barbut, D., W. A. Kinney, H. H. Chen, A. F. R. Stewart, J. Hecksher-Sørensen, C. Zhang, A. Fleming, M. Zemel, and M. Zasloff. 2024. “A novel, centrally acting mammalian aminosterol, ENT-03, induces weight loss in obese and lean rodents.” Diabetes, Obesity and Metabolism 26(12) (link).

Roostalu, U., H. H. Hansen, and J. Hecksher-Sørensen. 2024. “3D light-sheet fluorescence microscopy in preclinical and clinical drug discovery.” Drug Discovery Today 29(11) (link).

Reynolds, L. M., A. Gulmez, S. L. Fayad, R. C. Campos, D. Rigoni, C. Nguyen, T. Le Borgne, T. Topilko, ..., P. Faure. 2024. “Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state.” Nature Communications 15(1) (link).

Fayad, S. L., L. M. Reynolds, N. Torquet, S. Tolu, S. Mondoloni, C. Nguyen, A. Siriphanh, R. Justo, S. Didienne, N. Debray, C. Viollet, L. Raynaud, Y. Layadi, C. Fouquet, B. Hannesse, A. M. Capaz, T. Topilko, ..., P. Faure. 2024. “Individualistic reward-seeking strategies that predict response to nicotine emerge among isogenic male mice living in a micro-society.” PLoS Biology 22(10) (link).

Featured on the front cover

Skovbjerg, G., A. M. Fritzen, C. S. A. Svendsen, J. Perens, J. L. Skytte, C. Lund, J. Lund, M. R. Madsen, U. Roostalu, J. Hecksher-Sørensen, and C. Clemmensen. 2024. “Atlas of exercise-induced brain activation in mice.” Molecular Metabolism 82 (link). 

Fadahunsi, N., J. Petersen, S. Metz, A. Jakobsen, C. V. Mathiesen, A. S. Buch-Rasmussen, N. Kurgan, J. K. Larsen, R. C. Andersen, T. Topilko, ..., C. Clemmensen. 2024. “Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.” Science Advances 10(9) (link).

Dedic, N., L. Wang, E. Hajos-Korcsok, J. Hecksher-Sørensen, ..., K. S. Koblan. 2024. “TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding.” Molecular Metabolism 80 (link).

Falk, S., J. Petersen, C. Svendsen, C. R. Romero-Leguizamón, S. H. Jørgensen, N. Krauth, M. Q. Ludwig, K. Lundø, U. Roostalu, G. Skovbjerg, D. A. G. Nielsen, A. L. Ejdrup, T. H. Pers, O. Dmytriyeva, J. Hecksher-Sørensen, ..., C. Clemmensen. 2023. “GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity.” Cell Reports 42(5) (link).

Schneeberger, M., N. L. Brice, K. Pellegrino, L. Parolari, J. T. Shaked, K. J. Page, F. Marchildon, D. W. Barrows, T. S. Carroll, T. Topilko, ..., J. M. Friedman. 2022. “Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction.” Nature Metabolism 4(11) (link).

Topilko, T., S. L. Diaz, C. M. Pacheco, F. Verny, C. V. Rousseau, C. Kirst, C. Deleuze, P. Gaspar, and N. Renier. 2022. “Edinger-Westphal peptidergic neurons enable maternal preparatory nesting.” Neuron 110(8) (link).

Boland, B. B., R. C. Laker, S. O’Brien, S. Sitaula, I. Sermadiras, J. C. Nielsen, P. Barkholt, U. Roostalu, J. Hecksher-Sørensen, ..., C. J. Rhodes. 2022. “Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.” Molecular Metabolism 55 (link).

Skovbjerg, G., U. Roostalu, H. H. Hansen, T. A. Lutz, C. Le Foll, C. G. Salinas, J. L. Skytte, J. Jelsing, N. Vrang, and J. Hecksher-Sørensen. 2021. “Whole-brain mapping of amylin-induced neuronal activity in receptor activity-modifying protein 1/3 knockout mice.” European Journal of Neuroscience 54(1) (link).

Featured on the front cover

Hansen, Henrik H., Johanna Perens, Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Pernille Barkholt, Ditte Dencker Thorbek and Jacob Hecksher-Sørensen. 2021. “Whole-Brain Activation Signatures of Weight-Lowering Drugs.” Molecular Metabolism 47 (May). (link).

Kirst, C., S. Skriabine, A. Vieites-Prado, T. Topilko, ..., N. Renier. 2020. “Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature.” Cell 180(4) (link).

Voigt, F. F., D. Kirschenbaum, E. Platonova, S. Pagès, R. A. A. Campbell, R. Kastli, M. Schaettin, L. Egolf, A. van der Bourg, P. Bethge, K. Haenraets, N. Frézel, T. Topilko, ..., F. Helmchen. 2019. “The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue.” Nature Methods 16(11) (link).

Roostalu, U., C. B. G. Salinas, D. D. Thorbek, J. L. Skytte, K. Fabricius, P. Barkholt, L. M. John, V. I. Jurtz, L. B. Knudsen, J. Jelsing, N. Vrang, H. H. Hansen, and J. Hecksher-Sørensen. 2019. “Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson’s disease.” Disease Models & Mechanisms 12(11) (link).

Schneeberger, M., L. Parolari, T. Das Banerjee, V. Bhave, P. Wang, B. Patel, T. Topilko, ..., A. R. Nectow. 2019. “Regulation of Energy Expenditure by Brainstem GABA Neurons.” Cell 178(3) (link).

Salinas, C. B. G., T. T. H. Lu, S. Gabery, K. Marstal, T. Alanentalo, A. J. Mercer, A. Cornea, K. Conradsen, J. Hecksher-Sørensen, ..., A. Secher. 2018. “Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment.” Scientific Reports 8(1) (link).

Knudsen, L. B., A. Secher, J. Hecksher-Sørensen, and C. Pyke. 2016. “Long-acting glucagon-like peptide-1 receptor agonists have direct access to and effects on pro-opiomelanocortin/cocaine- and amphetamine-stimulated transcript neurons in the mouse hypothalamus.” Journal of Diabetes Investigation 7 (link).

Jensen, C. B., A. Secher, J. Hecksher-Sørensen, K. Conradsen, and R. Larsen. 2015. “Quantification of brain access of exendin-4 in the C57BL mouse model by SPIM fluorescence imaging and the Allen mouse brain reference model.” Lecture Notes in Computer Science (link).